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Entyvio (vedolizumab)

Editorial Team's avatar image

By Editorial Team

2 min read

Reviewed by: HU Medical Review Board | Last reviewed: August 2023 | Last updated: October 2023

Entyvio® (vedolizumab) is used to treat certain adults with moderate or severe inflammatory bowel diseases (IBD), including ulcerative colitis (UC) and Crohn’s disease (CD). Entyvio is used to treat adults for whom other anti-TNF medicines, corticosteroids, or immunomodulator medicines:1

  • Do not work well enough
  • Worked before but have stopped working
  • Cause a bad reaction

Entyvio is a biologic therapy called an integrin receptor antagonist.1

What are the ingredients in Entyvio?

The active ingredient in Entyvio is vedolizumab.1

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How does Entyvio work?

Entyvio contains a special antibody that works to reduce the inflammatory process in the digestive tract, which can be overactive in people with IBD. The antibodies in Entyvio target certain white blood cells and block a certain protein on the surface of the cells, which then prevents them from traveling out of the blood vessels and into a person’s tissues.1

Entyvio reduces inflammation in people with IBD by specifically affecting just the digestive tract. For some people with moderate to severe IBD, this can:1

  • Relieve their symptoms
  • Help them to enter remission

What are the possible side effects?

The most common side effects of Entyvio include:1

  • Common cold
  • Headache
  • Joint pain
  • Nausea
  • Fever
  • Nose or throat infections
  • Tiredness
  • Cough
  • Bronchitis
  • Flu
  • Back pain
  • Rash
  • Itching
  • Sinus infection
  • Throat pain
  • Pain in the arms, legs, hands, or feet

These are not all the possible side effects of Entyvio. Talk to your doctor about what to expect when taking Entyvio. You also should call your doctor if you have any changes that concern you when taking Entyvio.

Other things to know

Entyvio may be given in a vein (intravenously) or under the skin (subcutaneously). Your doctor will talk to you about what option is best for you.1

Your doctor may test you for tuberculosis (TB) before starting treatment with Entyvio.1

Before starting treatment with Entyvio, tell your doctor if you have:1

  • An infection, think you may have an infection, or have infections that keep coming back.
  • Liver problems.
  • TB or have been in close contact with someone with TB.
  • Have recently received or are scheduled to receive a vaccine. You may need to have certain vaccines before starting treatment with Entyvio.

There is not enough data to know if Entyvio is safe to take while pregnant or breastfeeding. Before starting treatment with Entyvio, tell your doctor if you are pregnant, planning to become pregnant, or breastfeeding.1

Before beginning treatment for ConditionName, tell your doctor about all your health conditions and any other drugs, vitamins, or supplements you are taking. This includes over-the-counter drugs.

For more information, read the full prescribing information of Entyvio.