Hi . Your frustration is certainly understandable. I did not find any research on vedolizumab and sexual function, but that absolutely does not mean there could not be a connection (my search is by no means exhaustive). There is research noting that a side effect of hysterectomy can be loss of sexual response (see: https://www.bumc.bu.edu/sexualmedicine/informationsessions/sexual-dysfunction-after-hysterectomy/#:~:text=Side%20effects%20of%20hysterectomy%20can,all%20be%20seen%20post%2Dhysterectomy.) Has your doctor had any thoughts on potential causes and treatments? Hoping you can get some answers soon. Best, Richard (Team Member)