I have had CD for about 20 years, a mild to moderate case that is allegedly in clinical remission but still having symptoms daily and have for years and years. I finally tracked my symptoms after almost being allowed into a clinical trial but screened out for symptoms that were not severe enough for the study. I have been on mesalamine nearly the whole time but feel like it does little for my symptoms. I even became non-compliant with my regimen for a while and felt no big difference in symptoms. I fall into a strange category of being ill enough to worry about cancer risk, had minor surgery (fissure repair and sphincterotomy ten years ago) but not severe enough for biologics or prednisone. I guess I am glad about that but at times I am worn out by the symptoms and fatigue that I do have. It seems like I have not met many mild to moderately affected people and wish that I knew more.