I took mesalamine for 12 years, but found that it didn't work for me as well, after I took it for a number of years. I tried alternative methods for a few years which included detoxing. I then tried to go back on mesalamine 1-2 years ago, but found out I'm allergic to it now. I'm currently taking supplements and vitamins for my mild/ moderate Crohn's. I get blood work done every 6 weeks to watch my liver function, cholesterol numbers, and many other functions.