Entyvio for ilieal crohns
Hi all,
I have moderate-severe crohns in my terminal ilieum. I was on remicade for 6mths which was effective at putting me in remission but caused lots of skin side effects so i went off it. I have started my first IV of entyvio and have not noticed any improvements. I am hoping it works given its safety profile. Does anyone have any experience they could share with entyvio for crohns? I've read it can take quite a while to kick in.
Thanks
Hi
. I can't personally speak on Entyvio, but I know that many medical sites mention that it can take 6 weeks for patients to notice improvement and up to 14 for the full effect (see here for example: https://www.medicalnewstoday.com/articles/drugs-how-long-does-it-take-for-entyvio-to-work). Of course, these are averages and hopefully you will experience some relief sooner. Also, hopefully others will chime in with their experiences. Best, Richard (Team Member) thank you, appreciate it
It took a couple of months to kick in, I was on it for 3 years and then started getting a lot of skin cancers. Dermatologists said it was sun damage from being in the sun as a child. I'm 75 do they think we believe them so I dug around and found so many sites that say people on biologics because they wreck your immune system are more prone to skin cancer. Then I came off biologics and I just watch my diet , and dont have any of the foods that we were told growing up were good for us - cabbage, cauliflower, mushrooms. Baked beans, spinach , etc, fried foods I keep to a minimum, but the best help I was given was being told little and often is better than big meals. I was told no fibre, then eat more fibre so it really is a game of trying to get it right. Funnily enough, prawns and mango, are my really red flags, they go straight through me !! It's hard trying to work it all out, some days are ok, some are awful and there doesn't seem to be an answer. Try not to get stressed out, eat food slowly, and try and get some gentle exercise is the only advice I can give, as well as ignoring all the annoying people who don't understand just what we go through on a daily basis. Chin up.
Hi
. It is great that you were able to get relief by making dietary and lifestyle changes. I do want to note that with IBD being an inflammatory autoimmune condition some patients will need treatment to help control the inflammation. Concerning the skin cancer, it is absolutely true that certain biologics have been found to increase the risk, although the level and what can varies pretty widely by biologic (see here for example: https://www.dermatologyadvisor.com/news/immunosuppressant-biologic-medication-use-may-increase-skin-cancer-risk). , I want to note that, in particular Entyvio (vedolizumab), has been found to have minimal risk. This research article discusses this, plus the types found to have higher risk, such as anti-TNFs and JAK inhibitors: https://www.mdpi.com/2072-6694/17/10/1710. It should also be noted that uncontrolled autoimmune inflammation is also known to be a cancer risk, such as IBD and an increased risk of colorectal cancer (see: https://www.cancercenter.com/risk-factors/autoimmune-diseases). Of course, every case is different and everyone has to determine their own level of risk (a friend referred to it as the risk to risk ratio), but I want to share the information. Best, Richard (Team Member)
