Hello everyone. Almost a year i have duodenal ulcers and gastric erosions. Ive passed 5 time gastroscopy and once colonoscopy. All the time the biopsy results were absolutely normal but yesterday i
ve received another one and need and explanation and help with it. Thanks in advance to everyone
1. Duodenu, biopsy:
-Ulcerated duodenal mucosa showing irregular, distorted villi, edema, mixed inflammatory infiltrate including tissue eosinophilia (30-40 EOS/HPF) and only 8-12 IEL/ columnar cells. The inflammatory cells spare duodenal crypts and penetrate into muscularis mucosa
-Negative for granulomas and dysplasia
-Consistent with chronic duodenitis with ulceration
Gastric antrum, biosy:
- Antral type mucosa with few erosions, foveolar hyperplasia, diffuse active inflammation and mild epithelial atypia. Acute and chronic inflammation including prominent tissue eosinophilia (30-40 EOS/HPF) is limited by lamina propria.
-Negative for granulomas
-Consistent with chronic gastritis, active
Comment: Giemsa stain negative for H.pylori
In summary, the findings may represent upper GIT involvement by Crohn-s disease in the context of existing IBD. However, isolated upper GI lesions with no colonic or ileal manifestation is extremely rare in adults.