I have been on UC medication for the past 18 months (taking mesalamine 3.2 gms and mesalamine suppository). I lost more than 15 pounds in a month before i started this medicine. I am doing better with this medication (even though not having much appetite). However, when I stopped mesalamine suppository for a month, my calprotectin levels went to 288 from 65 but I did not have any severe symptoms (just felt bloating for few days). Since I did not have any symptoms is this means I have active UC inside even though I am not feeling any change in my symptoms. Is calprotectin close to 300 very serious? please advise. Thanks for your support.