Talk with your doctor about prescribing you the antidepressant Desepramine. Been taking this 40 years. Just got a new gastroenterologist that uses this drug all the time for people with diarrhea. It is used because of the side effects which is constipaton. While this isn't a cure, it helps. A 25mg or 50 mg tablet is what works with me. To treat depression, you would be prescribed 200 to 300 mg a day. So I only took 1 tablet a day. I find taking it 30 minutes before breakfast helps my day. I took Asacol for 3 years, only to find out it did not dissolve AT ALL.